Tnfsf11^tm1.1Htaka
Targeted Allele Detail

Summary

• Symbol: Tnfsf11^tm1.1Htaka
• Name: tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1.1, Hiroshi Takayanagi
• MGI ID: MGI:5297060
• Synonyms: Rankl^fl, Tnfsf11^flox
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^tm1.1Htaka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177557
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette. (J:177557)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 32 strains or lines available

References

• Original: J:177557 Nakashima T, et al., Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 2011;17(10):1231-4
• All: 9 reference(s)