Pglyrp4^tm1Rdz
Targeted Allele Detail

Summary

• Symbol: Pglyrp4^tm1Rdz
• Name: peptidoglycan recognition protein 4; targeted mutation 1, Roman Dziarski
• MGI ID: MGI:5297107
• Gene: Pglyrp4 Location: Chr3:90634213-90648824 bp, + strand Genetic Position: Chr3, 39.96 cM, cytoband F1
• Alliance: Pglyrp4^tm1Rdz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178054
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neo cassette. Quantitative RT-PCR confirmed the absence of transcript expression. (J:178054)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pglyrp4 Mutation: 15 strains or lines available

References

• Original: J:178054 Saha S, et al., PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe. 2009 Feb 19;5(2):137-50
• All: 6 reference(s)