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Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Bernhard G Herrmann
MGI ID: MGI:5297162
Synonyms: KD4-T
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh page
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:173434
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Knockdown, RMCE-ready)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
  Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh involves 1 genes/genome features (T) View all
 
Mutation detailsRecombinase mediated cassette exchange was used to insert two short hairpin RNAi specific for the Brachyury (T) gene under the control of tetO followed by a PGK promoter into the Gt(ROSA)26Sortm2Bgh allele. Expression of the shRNAi requires treatment with doxycycline. (J:173434)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  991 strains or lines available
Notes
Both C57BL/6 and G4 Es cells were used for targeting.
References
Original:  J:173434 Vidigal JA, et al., An inducible RNA interference system for the functional dissection of mouse embryogenesis. Nucleic Acids Res. 2010 Jun 1;38(11):e122
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory