Snap25^tm1Mtaka
Targeted Allele Detail

Summary

• Symbol: Snap25^tm1Mtaka
• Name: synaptosomal-associated protein 25; targeted mutation 1, Masami Takahashi
• MGI ID: MGI:5297219
• Synonyms: Snap25^S187A
• Gene: Snap25 Location: Chr2:136555373-136624348 bp, + strand Genetic Position: Chr2, 67.56 cM
• Alliance: Snap25^tm1Mtaka page

Abnormal locomotor activity in open field in Snap25^tm1Mtaka/Snap25^tm1Mtaka mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177870
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Not Specified) Mutations: Insertion, Nucleotide substitutions Mutation details: A minigene containing a cDNA with nucleotide substitution(s) that results in the amino acid substitution of alanine for serine at position 187 (S187A) and a neo cassette were inserted into exon 7. (J:177870)

Generation of the Snap25^tm1Mtaka allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snap25 Mutation: 26 strains or lines available

References

• Original: J:177870 Kataoka M, et al., A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse. PLoS One. 2011;6(9):e25158
• All: 4 reference(s)