Epb41l3^tm1.1Jglt
Targeted Allele Detail

Summary

• Symbol: Epb41l3^tm1.1Jglt
• Name: erythrocyte membrane protein band 4.1 like 3; targeted mutation 1.1, Jean-Antoine Girault
• MGI ID: MGI:5297225
• Synonyms: protein 4.1B^KO3
• Gene: Epb41l3 Location: Chr17:69382678-69596984 bp, + strand Genetic Position: Chr17, 40.15 cM
• Alliance: Epb41l3^tm1.1Jglt page

Limb clasping and gait abnormalities in Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177866
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. A floxed hygro-GFP cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the hygro-GFP cassette. The absence of protein expression was confirmed by western blot analysis on brain and sciatic nerve extract. (J:177866)

Generation of the Epb41l3^tm1.1Jglt allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epb41l3 Mutation: 46 strains or lines available

References

• Original: J:177866 Cifuentes-Diaz C, et al., Protein 4.1B contributes to the organization of peripheral myelinated axons. PLoS One. 2011;6(9):e25043
• All: 4 reference(s)