Gab2^tm3.1Thir
Targeted Allele Detail

Summary

• Symbol: Gab2^tm3.1Thir
• Name: growth factor receptor bound protein 2-associated protein 2; targeted mutation 3.1, Toshio Hirano
• MGI ID: MGI:5297247
• Synonyms: Gab2^deltaSHP2
• Gene: Gab2 Location: Chr7:96730958-96958158 bp, + strand Genetic Position: Chr7, 53.39 cM, cytoband E2
• Alliance: Gab2^tm3.1Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178045
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6Jcl x 129T/SvJcl

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cDNA encoding amino acids 89-665 was inserted into exon 2, in which nucleotide substitutions result in the amino acid substitution of phenylalanine for tyrosine at positions 603 and 632 abolishing the SHP2-binding domain (Y603F and Y632F). A floxed neo cassette inserted downstream of exon 2 was removed by cre-mediated recombination. (J:178045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gab2 Mutation: 37 strains or lines available

References

• Original: J:178045 Nishida K, et al., Gab2, via PI-3K, regulates ARF1 in FcepsilonRI-mediated granule translocation and mast cell degranulation. J Immunol. 2011 Jul 15;187(2):932-41
• All: 1 reference(s)