Gab2^tm4.1Thir
Targeted Allele Detail

Summary

• Symbol: Gab2^tm4.1Thir
• Name: growth factor receptor bound protein 2-associated protein 2; targeted mutation 4.1, Toshio Hirano
• MGI ID: MGI:5297248
• Synonyms: Gab2^deltaPI3K
• Gene: Gab2 Location: Chr7:96730958-96958158 bp, + strand Genetic Position: Chr7, 53.39 cM, cytoband E2
• Alliance: Gab2^tm4.1Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178045
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6Jcl x 129T/SvJcl

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A cDNA encoding amino acids 89-665 was inserted into exon 2, in which nucleotide substitutions that results in the amino acid substitution of phenylalanine for tyrosine at positions 441, 465, and 573 (Y441F, Y465F, Y573F) abolishing the PI3K-binding domain. A floxed neo cassette inserted downstream of exon 2 was removed by cre-mediated recombination. (J:178045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gab2 Mutation: 37 strains or lines available

References

• Original: J:178045 Nishida K, et al., Gab2, via PI-3K, regulates ARF1 in FcepsilonRI-mediated granule translocation and mast cell degranulation. J Immunol. 2011 Jul 15;187(2):932-41
• All: 1 reference(s)