Tnfsf11^tm1.1Caob
Targeted Allele Detail

Summary

• Symbol: Tnfsf11^tm1.1Caob
• Name: tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1.1, Charles O'Brien
• MGI ID: MGI:5297355
• Synonyms: RANKLf
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^tm1.1Caob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177558
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 3 and 4 floxed. (J:177558)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 32 strains or lines available

References

• Original: J:177558 Xiong J, et al., Matrix-embedded cells control osteoclast formation. Nat Med. 2011;17(10):1235-41
• All: 17 reference(s)