b2b145Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b145Clo
• Name: Mutant line 145; Bench to Bassinet Program (B2B/CVDC), mutation 145 Cecilia Lo
• MGI ID: MGI:5297418
• Gene: b2b145Clo Location: unknown
• Alliance: b2b145Clo page

Preductal coarctation of the aorta

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b145Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis
Cardiovascular defects: Perimembranous or muscular ventricular septal defect (VSD), Dilated atria
Non-cardiovascular defects: Kidney anomalies
Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1310	Ventricular septal defect, membranous
1320	Ventricular septal defect, muscular
2720	Right aortic arch
3804	Congenital heart disease
4512	Renal malformation

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)