Oxsr1^tm1.2Ssy
Targeted Allele Detail

Summary

• Symbol: Oxsr1^tm1.2Ssy
• Name: oxidative-stress responsive 1; targeted mutation 1.2, Sung-Sen Yeh
• MGI ID: MGI:5297492
• Synonyms: OSR1^-
• Gene: Oxsr1 Location: Chr9:119067498-119151493 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Oxsr1^tm1.2Ssy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177443
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 9 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 10 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exons 9 and 10. (J:177443)

Generation of the Oxsr1^tm1.1Ssy and Oxsr1^tm1.2Ssy alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxsr1 Mutation: 41 strains or lines available

References

• Original: J:177443 Lin SH, et al., Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43
• All: 4 reference(s)