Inpp4b^tm1.1Jva
Targeted Allele Detail

Summary

• Symbol: Inpp4b^tm1.1Jva
• Name: inositol polyphosphate-4-phosphatase, type II; targeted mutation 1.1, Jean Vacher
• MGI ID: MGI:5297505
• Synonyms: Inpp4b^delta11
• Gene: Inpp4b Location: Chr8:82069185-82854543 bp, + strand Genetic Position: Chr8, 39.02 cM
• Alliance: Inpp4b^tm1.1Jva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177648
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 11. Cre-mediated recombination removed the neo cassette and exon 11. The absence of protein expression was confirmed by western blot analysis on osteoclast extracts. (J:177648)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inpp4b Mutation: 69 strains or lines available

References

• Original: J:177648 Ferron M, et al., Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab. 2011 Oct 5;14(4):466-77
• All: 6 reference(s)