Tg(Vsx2-cre)2690Chow
Transgene Detail

Summary

• Symbol: Tg(Vsx2-cre)2690Chow
• Name: transgene insertion 2690, Robert L Chow
• MGI ID: MGI:5297524
• Synonyms: Vsx2-5.3-PRE-Cre
• Transgene: Tg(Vsx2-cre)2690Chow Location: unknown
• Alliance: Tg(Vsx2-cre)2690Chow page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Vsx2-cre)2690Chow expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Vsx2

• Mutation details: Cre recombinase cDNA was cloned downstream of a 5.3kb upstream region of the Vsx2 gene. A 1.9 kb region containing a 164 bp bipolar enhancer was cloned 5' of the 5.3 kb region. An SV40 polyadenylation sequence was inserted downstream of cre. The 1.9 kb region has been identified as a putative retinal enhancer (PRE) and lies within a conserved non-coding region that is within the breakpoint of the Vsx2 (ocular retardation 2J) mutation. 6 founder lines carried the transgene, with 4 (2690, 2695, 2700, and 2717) exhibiting cre expression detected by immunolabeling. (J:178063)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vsx2 (species not specified) Summary of all recombinase alleles driven by Vsx2.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:178063 Nickerson PE, et al., A transgenic mouse line expressing cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors. PLoS One. 2011;6(10):e27145
• All: 8 reference(s)