Cd68^tm1Xfen
Targeted Allele Detail

Summary

• Symbol: Cd68^tm1Xfen
• Name: CD68 antigen; targeted mutation 1, Xu Feng
• MGI ID: MGI:5297542
• Gene: Cd68 Location: Chr11:69555039-69556979 bp, - strand Genetic Position: Chr11, 42.86 cM
• Alliance: Cd68^tm1Xfen page

Cd68^tm1Xfen/Cd68^tm1Xfen mice have increased trabecular bone and decreased trabecular tissue mineral density

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178120
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1 and 2 were replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on bone marrow-derived macrophage. (J:178120)

Generation of the Cd68^tm1Xfen allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd68 Mutation: 33 strains or lines available

References

• Original: J:178120 Ashley JW, et al., Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts. PLoS One. 2011;6(10):e25838
• All: 1 reference(s)