Ighm^tm1Bhe
Targeted Allele Detail

Summary

• Symbol: Ighm^tm1Bhe
• Name: immunoglobulin heavy constant mu; targeted mutation 1, Birgitta Heyman
• MGI ID: MGI:5297544
• Synonyms: Cmu13
• Gene: Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
• Alliance: Ighm^tm1Bhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177421
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Not Specified) Mutations: Insertion, Single point mutation Mutation details: A C to T point mutation was introduced into the gene coding for the third C domain of the mu-heavy chain causing the amino acid encoded by codon 436 to change from proline to serine. A floxed neomycin was inserted as well. This neo cassette was subsequently excised from correctly targeted mice. (J:177421, J:178135, J:178136)

Generation of the Ighm^tm1Bhe allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighm Mutation: 56 strains or lines available

References

• Original: J:177421 Rutemark C, et al., Requirement for complement in antibody responses is not explained by the classic pathway activator IgM. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E934-42
• All: 5 reference(s)