Fstl1^tm1.1Mvdh
Targeted Allele Detail

Summary

• Symbol: Fstl1^tm1.1Mvdh
• Name: follistatin-like 1; targeted mutation 1.1, Maurice JB van den Hoff
• MGI ID: MGI:5297548
• Synonyms: Fstl1^flox
• Gene: Fstl1 Location: Chr16:37597417-37656878 bp, + strand Genetic Position: Chr16, 26.48 cM
• Alliance: Fstl1^tm1.1Mvdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176532
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Homologous recombination inserted an FRT-flanked neo cassette followed by an loxP site downstream of exon 2. An additional loxP site inserted upstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:176532)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fstl1 Mutation: 46 strains or lines available

References

• Original: J:176532 Sylva M, et al., The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One. 2011;6(8):e22616
• All: 7 reference(s)