Tg(SOD1*H46R)#Maw
Transgene Detail

Summary

• Symbol: Tg(SOD1*H46R)#Maw
• Name: transgene insertion, Manabu Wada
• MGI ID: MGI:5297587
• Synonyms: H46R SOD1 Tg
• Transgene: Tg(SOD1*H46R)#Maw Location: unknown
• Alliance: Tg(SOD1*H46R)#Maw page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*H46R)#Maw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: An 11.5kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine. (J:99701)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99701 Chang-Hong R, et al., Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol. 2005 Jul;194(1):203-11
• All: 6 reference(s)