Foxn1^tm1.1Cbln
Targeted Allele Detail

Summary

• Symbol: Foxn1^tm1.1Cbln
• Name: forkhead box N1; targeted mutation 1.1, C Clare Blackburn
• MGI ID: MGI:5297717
• Synonyms: Foxn1^R
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^tm1.1Cbln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177992
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1b followed by a splice acceptor, SV40 T antigen, IRESEGFP/neo and aCMAZ transcriptional pause. This was followed immediately by a floxed blasticidin-S deaminase sequence. The blasticidin selection cassette was excised from properly targeted ES cells. Very low levels of protein can still be detected in homozygous mice (hypomorphic). (J:177992)

Expression

In Mice Carrying this Mutation:	50 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:177992 Nowell CS, et al., Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 2011 Nov;7(11):e1002348
• All: 2 reference(s)