Lrrc7^tm1.1Mabk
Targeted Allele Detail

Summary

• Symbol: Lrrc7^tm1.1Mabk
• Name: leucine rich repeat containing 7; targeted mutation 1.1, Mary B Kennedy
• MGI ID: MGI:5297824
• Gene: Lrrc7 Location: Chr3:157772823-158268254 bp, - strand Genetic Position: Chr3, Syntenic
• Alliance: Lrrc7^tm1.1Mabk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177836
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed hygro cassette was inserted downstream of exon 3. Cre-mediated recombination removed the hygro cassette and exon 3. The absence of protein expression was confirmed by western blot analysis on forebrain extracts. (J:177836)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc7 Mutation: 94 strains or lines available

References

• Original: J:177836 Carlisle HJ, et al., Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction. J Neurosci. 2011 Nov 9;31(45):16194-207
• All: 2 reference(s)