Map2k7^tm1Rjd
Targeted Allele Detail

Summary

• Symbol: Map2k7^tm1Rjd
• Name: mitogen-activated protein kinase kinase 7; targeted mutation 1, Roger J Davis
• MGI ID: MGI:5297854
• Synonyms: mkk7^fl
• Gene: Map2k7 Location: Chr8:4288740-4297897 bp, + strand Genetic Position: Chr8, 1.99 cM, cytoband A1.1
• Alliance: Map2k7^tm1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178060
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 4-7 were floxed. (J:186492)

Tumor Data

List all tumor models in MMHCdb carrying Map2k7^tm1Rjd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k7 Mutation: 20 strains or lines available

References

• Original: J:178060 Mazzitelli S, et al., The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo. J Neurosci. 2011 Nov 23;31(47):16969-76
• All: 10 reference(s)