Sirt5^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Sirt5^tm1.1Ics
• Name: sirtuin 5; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5297911
• Gene: Sirt5 Location: Chr13:43518972-43548679 bp, + strand Genetic Position: Chr13, 21.6 cM
• Alliance: Sirt5^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177830
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was flanked by loxP sites. Cre-mediated recombination removed exon 4. The absence of protein expression was confirmed by western blot analysis. (J:177830)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt5 Mutation: 29 strains or lines available

References

• Original: J:177830 Du J, et al., Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011 Nov 11;334(6057):806-9
• All: 6 reference(s)