Gria4^tm1Yfkk
Targeted Allele Detail

Summary

• Symbol: Gria4^tm1Yfkk
• Name: glutamate receptor, ionotropic, AMPA4 (alpha 4); targeted mutation 1, Yasuyuki Fukumaki
• MGI ID: MGI:5298021
• Gene: Gria4 Location: Chr9:4417896-4796234 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Gria4^tm1Yfkk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178206
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 12 was replaced with a neo cassette. Western blot analysis confirmed the absence of protein expression in the cerebrum and cerebellum. (J:178206)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria4 Mutation: 72 strains or lines available

References

• Original: J:178206 Sagata N, et al., Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function. Genes Brain Behav. 2010 Nov;9(8):899-909
• All: 1 reference(s)