Tg(CAG-cat,-Dcn*)#Debi
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-Dcn*)#Debi
• Name: transgene insertion, David E Birk
• MGI ID: MGI:5298093
• Synonyms: 925delTDcn
• Transgene: Tg(CAG-cat,-Dcn*)#Debi Location: unknown
• Alliance: Tg(CAG-cat,-Dcn*)#Debi page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-cat,-Dcn*)#Debi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dcn (MGI:94872)

• Mutation details: This transgene consists of the ubiquitous CAG promoter followed by a floxed chloramphenicol acetyltransferase (cat) gene and a mutant murine Dcn cDNA with a single base pair deletion at position 952 (delT) resulting in a frameshift mutation and truncation of the C terminal 33 amino acids. The mutation at position 952 in the mouse gene is comparable to the mutation in position 967 in the human gene seen in patients with congenital stromal corneal dystrophy. Cre mediated recombination results in expression of the mutant mouse cDNA. (J:177392)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:177392 Chen S, et al., Pathophysiological mechanisms of autosomal dominant congenital stromal corneal dystrophy C-terminal-truncated decorin results in abnormal matrix assembly and altered expression of small leucine-rich proteoglycans. Am J Pathol. 2011 Nov;179(5):2409-19
• All: 2 reference(s)