Mapt^{tm1(Setdb1)Akba}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm1(Setdb1)Akba}
• Name: microtubule-associated protein tau; targeted mutation 1, Schahram Akbarian
• MGI ID: MGI:5298877
• Synonyms: tauSetdb1
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm1(Setdb1)Akba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178512
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The myc-tagged mouse cDNA and a neo cassette were inserted downstream of the start codon in exon 2. Western blot analysis confirmed protein expression in the cerebral cortex, striatum, hippocampus, cerebellum, thalamus, hypothalamus, peri-aqueductal gray, and substantia nigra. (J:178512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:178512 Jiang Y, et al., Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. 2011 Jun;60(7-8):1088-97
• All: 1 reference(s)