Pax8^tm1Rdl
Targeted Allele Detail

Summary

• Symbol: Pax8^tm1Rdl
• Name: paired box 8; targeted mutation 1, Roberto Di Lauro
• MGI ID: MGI:5299327
• Synonyms: Pax8^fl, Pax8^Floxed
• Gene: Pax8 Location: Chr2:24310572-24365611 bp, - strand Genetic Position: Chr2, 16.43 cM, cytoband B
• Alliance: Pax8^tm1Rdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178498
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP sequence was inserted upstream of exon 3, followed by a second loxP site and a frt-flanked neomycin cassette in intron 4. Flp-mediated recombination removed the neomycin casette. (J:178498, J:220108)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax8 Mutation: 32 strains or lines available

References

• Original: J:178498 Fagman H, et al., Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011 Nov 15;359(2):163-75
• All: 3 reference(s)