Creb1^tm1.1Berd
Targeted Allele Detail

Summary

• Symbol: Creb1^tm1.1Berd
• Name: cAMP responsive element binding protein 1; targeted mutation 1.1, Rebecca Berdeaux
• MGI ID: MGI:5299333
• Synonyms: Creb^Y134F, Creb^YF, Creb^YF(deltaneo)
• Gene: Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
• Alliance: Creb1^tm1.1Berd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177923
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Single point mutation Mutation details: Exon 5 was replaced with a floxed neo cassette and a modified exon 5 in which nucleotide substitution results in the amino acid substitution of phenylalanine for tyrosine at postion 134 (Y134F). Cre-mediated recombination removed the neo cassette. (J:177923)

Generation of hte Creb1^tm1.1Berd allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creb1 Mutation: 61 strains or lines available

References

• Original: J:177923 Stewart R, et al., CREB is activated by muscle injury and promotes muscle regeneration. PLoS One. 2011;6(9):e24714
• All: 1 reference(s)