Scrib^tm1.2Phum
Targeted Allele Detail

Summary

• Symbol: Scrib^tm1.2Phum
• Name: scribbled planar cell polarity; targeted mutation 1.2, Patrick O Humbert
• MGI ID: MGI:5299427
• Gene: Scrib Location: Chr15:75919011-75941633 bp, - strand Genetic Position: Chr15, 35.29 cM
• Alliance: Scrib^tm1.2Phum page

Craniorachischisis in Scrib^tm1.2Phum/Scrib^tm1.2Phum mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exons 4 through 13 from Scrib^tm1.1Phum. Western blot analysis confirmed the absence of protein expression in embryos. (J:178461)

Generation of the Scrib^tm1.1Phum and Scrib^tm1.2Phum alleles

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scrib Mutation: 54 strains or lines available

References

• Original: J:178461 Pearson HB, et al., SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest. 2011 Nov 1;121(11):4257-67
• All: 5 reference(s)