Y(IsXPAR;Y)Ei
Spontaneous Allele Detail

Summary

• Symbol: Y(IsXPAR;Y)Ei
• Name: Chr Y, insertion of X PAR region to Y PAR region, Eva Eicher; Chr Y, insertion of X pseudoautosomal region to Y pseudoautosomal region, Eicher
• MGI ID: MGI:5300493
• Synonyms: T8Ei, T(XA1?;InY)8Ei, Y*, Y star
• Gene: Y(IsXPAR;Y)Ei Location: unknown Genetic Position: ChrY, Syntenic

Mutation origin

• Strain of Origin: LT/Sv

Mutation description

• Allele Type: Spontaneous
• Mutation: Translocation
• Mutation details: The Y* PAR chromosome has resulted from an end to end fusion of an X and a Y PAR. Furthermore, it was shown that in conjuction with this PAR-PAR fusion, there has been a deletion of both copies of the distally located pseudoautosomal gene Steroid sulfatase (Sts). The arrangement of the two PAR regions permits reciprocal translocation of X and Y chromatin at every meiotic event in the male resulting in half of the sperm produced bearing one of two abnormal sex chromosome. (J:60, J:48823)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Y(IsXPAR;Y)Ei Mutation: 3 strains or lines available

References

• Original: J:2277 Eicher EM, et al., The mouse Y* chromosome involves a complex rearrangement, including interstitial positioning of the pseudoautosomal region. Cytogenet Cell Genet. 1991;57(4):221-30
• All: 37 reference(s)