Lepr^tm5Mgmj
Targeted Allele Detail

Summary

• Symbol: Lepr^tm5Mgmj
• Name: leptin receptor; targeted mutation 5, Martin G Myers, Jr
• MGI ID: MGI:5301119
• Synonyms: lepr^F1077
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm5Mgmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179119
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting vector contained a nucleotide substitution that results in the amino acid substitution of phenyalanine for tyrosine at position 1077 (Y1077F) and a floxed NEO cassette. This mutation is predicted to abolish STAT5 activation by the mutated protein. (J:179119)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:179119 Myers MG, Direct Data Submission 2012/01/11. MGI Direct Data Submission. 2012
• All: 2 reference(s)