Ngfr^tm1.2Vk
Targeted Allele Detail

Summary

• Symbol: Ngfr^tm1.2Vk
• Name: nerve growth factor receptor (TNFR superfamily, member 16); targeted mutation 1.2, Vesa Kaartinen
• MGI ID: MGI:5301294
• Synonyms: p75^NTR-KO
• Gene: Ngfr Location: Chr11:95459644-95478524 bp, - strand Genetic Position: Chr11, 59.01 cM
• Alliance: Ngfr^tm1.2Vk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178666
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 through 6. Western blot analysis on liver and brain extracts confirmed the absence of protein expression. (J:178666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ngfr Mutation: 33 strains or lines available

References

• Original: J:178666 Bogenmann E, et al., Generation of mice with a conditional allele for the p75(NTR) neurotrophin receptor gene. Genesis. 2011 Nov;49(11):862-9
• All: 2 reference(s)