Mecom^tm1Aspe
Targeted Allele Detail

Summary

• Symbol: Mecom^tm1Aspe
• Name: MDS1 and EVI1 complex locus; targeted mutation 1, Archibald Perkins
• MGI ID: MGI:5301305
• Synonyms: Mds1-Evi1^tm1ap, ME^m1
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^tm1Aspe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178429
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/neo cassette was inserted downstream of the translation initiation site. RNA analysis of adult tissues showed that MDS1-EVI1 (ME) transcripts are undetectable in all tissues except for a very low level in kidney, whereas levels of Evi1 mRNAs are normal. (J:178429)

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:178429 Zhang Y, et al., PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood. 2011 Oct 6;118(14):3853-61
• All: 4 reference(s)