Mecom^tm2.1Aspe
Targeted Allele Detail

Summary

• Symbol: Mecom^tm2.1Aspe
• Name: MDS1 and EVI1 complex locus; targeted mutation 2.1, Archibald Perkins
• MGI ID: MGI:5301306
• Synonyms: Evi1^fl3, ME^fl4
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^tm2.1Aspe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178429
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and left exon 3 floxed. (J:178429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:178429 Zhang Y, et al., PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood. 2011 Oct 6;118(14):3853-61
• All: 4 reference(s)