Rgs6^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Rgs6^tm1Lex
• Name: regulator of G-protein signaling 6; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5301342
• Gene: Rgs6 Location: Chr12:82663325-83208835 bp, + strand Genetic Position: Chr12, 38.14 cM
• Alliance: Rgs6^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178185
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A "gene trapping" cassette containing IRES, betaGeo and PGK1-puro sequence was inserted in place of part of exon 5 and all of exons 6 and 7. Absence of protein in the heart was verified by immunoblot analysis. (J:178182, J:178185)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rgs6 Mutation: 31 strains or lines available

References

• Original: J:178185 Yang J, et al., RGS6, a modulator of parasympathetic activation in heart. Circ Res. 2010 Nov 26;107(11):1345-9
• All: 18 reference(s)