Tet2^tm1.1Mjxu
Targeted Allele Detail

Summary

• Symbol: Tet2^tm1.1Mjxu
• Name: tet methylcytosine dioxygenase 2; targeted mutation 1.1, Mingjiang Xu
• MGI ID: MGI:5301343
• Synonyms: Tet2:nlacZ/nGFP
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^tm1.1Mjxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178415
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct (containing a floxed lacZ with a nuclear localization signal, a nuclear GFP (H2B-GFP or nGFP), and an FRT-flanked neo cassette) was inserted upstream of the translation initiation site in exon 3. Flp-mediated recombination removed the neo cassette. (J:178415)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 779 strains or lines available

References

• Original: J:178415 Li Z, et al., Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011 Oct 27;118(17):4509-18
• All: 17 reference(s)