Tg(Cpa3-cre)3Glli
Transgene Detail

Summary

• Symbol: Tg(Cpa3-cre)3Glli
• Name: transgene insertion 3, Stephen J Galli
• MGI ID: MGI:5301437
• Synonyms: Cpa3-Cre
• Transgene: Tg(Cpa3-cre)3Glli Location: unknown
• Alliance: Tg(Cpa3-cre)3Glli page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cpa3-cre)3Glli expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cpa3

• Mutation details: A 780 bp fragment corresponding to the region immediately 5' to the start codon of the Cpa3 gene was used to drive expression of cre recombinase in the transgene construct. The Cpa3-cre construct was microinjected into C57BL/6-derived embryonic stem (ES) cells. Analysis of mice generated in crosses of cre transgenic to dual reporter (mT/mG) animals showed that most (about 89%) of peritoneal mast cells exhibit high levels of recombination whereas only 13-15% of granulocytes (basophils, eosinophils and neutrophils) display significant recombination. (J:179080)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cpa3 (species not specified) Summary of all recombinase alleles driven by Cpa3.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:179080 Lilla JN, et al., Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood. 2011 Dec 22;118(26):6930-8
• All: 24 reference(s)