Cdkal1^tm1.1Tomik
Targeted Allele Detail

Summary

• Symbol: Cdkal1^tm1.1Tomik
• Name: CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.1, Kazuhito Tomizawa
• MGI ID: MGI:5301441
• Synonyms: Cdkal1^flox
• Gene: Cdkal1 Location: Chr13:29375729-30039657 bp, - strand Genetic Position: Chr13, 12.93 cM, cytoband A3.3
• Alliance: Cdkal1^tm1.1Tomik page

Endoplasmic reticulum distention in Cdkal1^tm1.2Tomik/Cdkal1^tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178248
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed. (J:178248)

Generation of the Cdkal1^tm1.1Tomik and Cdkal1^tm1.2Tomik alleles

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkal1 Mutation: 60 strains or lines available

References

• Original: J:178248 Wei FY, et al., Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011 Sep 1;121(9):3598-608
• All: 2 reference(s)