Jam2^tm1.2Rha
Targeted Allele Detail

Summary

• Symbol: Jam2^tm1.2Rha
• Name: junction adhesion molecule 2; targeted mutation 1.2, Ralf H Adams
• MGI ID: MGI:5301450
• Synonyms: Jam-b^-
• Gene: Jam2 Location: Chr16:84571011-84622816 bp, + strand Genetic Position: Chr16, 46.92 cM
• Alliance: Jam2^tm1.2Rha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178387
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 fused to a murine cDNA (codons 165-298, PEY...SFII*) with a 3' loxP. An FRT-flanked neo cassette was inserted downstream of exon 5. Flp- and cre-mediated recombination removed the neo cassette and modified exon 5, respectively. (J:178387)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jam2 Mutation: 121 strains or lines available

References

• Original: J:178387 Arcangeli ML, et al., JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Blood. 2011 Oct 27;118(17):4609-19
• All: 5 reference(s)