Rc3h1^tm1.2Mass
Targeted Allele Detail

Summary

• Symbol: Rc3h1^tm1.2Mass
• Name: RING CCCH (C3H) domains 1; targeted mutation 1.2, Marc Schmidt-Supprian
• MGI ID: MGI:5301574
• Synonyms: Roquin^-
• Gene: Rc3h1 Location: Chr1:160733988-160802548 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Rc3h1^tm1.2Mass page

Curly tail, skin, soft tissue and bone defect, and alveoli that are not properly expanded in Rc3h1^tm1.2Mass/Rc3h1^tm1.2Mass mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177784
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Rc3h1^tm1.1Mass removed exons 4 through 6. Western blot analysis confirmed the absence of protein expression on mouse embryonic fibroblast extracts. (J:177784)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rc3h1 Mutation: 42 strains or lines available

References

• Original: J:177784 Bertossi A, et al., Loss of Roquin induces early death and immune deregulation but not autoimmunity. J Exp Med. 2011 Aug 29;208(9):1749-56
• All: 2 reference(s)