Cop1^{Gt(XR0653)1.1Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Cop1^{Gt(XR0653)1.1Wtsi}
• Name: COP1, E3 ubiquitin ligase; gene trap XR0653, 1.1 Welcome Trust Sanger Institute
• MGI ID: MGI:5301600
• Synonyms: Cop1^h, Cop1^hypo
• Gene: Cop1 Location: Chr1:159059890-159175210 bp, + strand Genetic Position: Chr1, 69.03 cM, cytoband C3
• Alliance: Cop1^{Gt(XR0653)1.1Wtsi} page

Mutation origin

• Mutant Cell Line: XR0653
• Germline Transmission: Earliest citation of germline transmission: J:178271
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxf
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. Gene trap vector is inserted in intron 6. The floxed "SA" element was then removed by cre excision. Mice carrying one copy of this allele produce only about 5% of control levels of protein while homozygotes produce 10% of control levels at E9.5 as determined by Western Blot. (J:178271)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cop1^{Gt(XR0653)1.1Wtsi}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cop1 Mutation: 44 strains or lines available

References

• Original: J:178271 Migliorini D, et al., Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. J Clin Invest. 2011 Apr 1;121(4):1329-43
• All: 1 reference(s)