Atxn1l^tm2.1Hzo
Targeted Allele Detail

Summary

• Symbol: Atxn1l^tm2.1Hzo
• Name: ataxin 1-like; targeted mutation 2.1, Huda Y Zoghbi
• MGI ID: MGI:5301616
• Gene: Atxn1l Location: Chr8:110453083-110464371 bp, - strand Genetic Position: Chr8, 57.22 cM
• Alliance: Atxn1l^tm2.1Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178303
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the open reading frame and a floxed neo cassette was inserted downstream of the open reading frame via homologous recombination. Cre mediated recombination removed the open reading frame and the neo cassette.

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atxn1l Mutation: 24 strains or lines available

References

• Original: J:178303 Lee Y, et al., ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011 Oct 18;21(4):746-57
• All: 2 reference(s)