Tg(Nphs1-Ptgs2)14Rhrs
Transgene Detail

Summary

• Symbol: Tg(Nphs1-Ptgs2)14Rhrs
• Name: transgene insertion 14, Raymond Harris
• MGI ID: MGI:5301702
• Synonyms: Cox-2 Tg, Nephrin-COX-2-Tg
• Transgene: Tg(Nphs1-Ptgs2)14Rhrs Location: unknown
• Alliance: Tg(Nphs1-Ptgs2)14Rhrs page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Nphs1-Ptgs2)14Rhrs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptgs2 (MGI:97798)

• Mutation details: The mouse Ptgs2, prostaglandin-endoperoxide synthase 2 (Cox-2), gene was placed under the control of a 8.5-kb fragment containing the promoter of the mouse Nphs1, nephrosis 1 homolog. (J:148158)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:148158 Cheng H, et al., Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol. 2007 Feb;18(2):551-9
• All: 3 reference(s)