Sting1^tm1Camb
Targeted Allele Detail

Summary

• Symbol: Sting1^tm1Camb
• Name: stimulator of interferon response cGAMP interactor 1; targeted mutation 1, John C Cambier
• MGI ID: MGI:5301711
• Synonyms: MPYS^-, Tmem173^-
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^tm1Camb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179270
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An Frt flanked neo cassette followed by a loxP site was inserted intron 5. A second loxP site was inserted in intron 2. Western blot analysis of splenocyte proteins and intracellular staining of peripheral blood confirmed the absence of protein product. Absence of transcript was confirmed by RT-PCR. (J:179270)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 51 strains or lines available

References

• Original: J:179270 Jin L, et al., MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 1;187(5):2595-601
• All: 20 reference(s)