Maml3^tm1Mkit
Targeted Allele Detail

Summary

• Symbol: Maml3^tm1Mkit
• Name: mastermind like transcriptional coactivator 3; targeted mutation 1, Motoo Kitagawa
• MGI ID: MGI:5301728
• Gene: Maml3 Location: Chr3:51595032-52012740 bp, - strand Genetic Position: Chr3, 22.54 cM
• Alliance: Maml3^tm1Mkit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178680
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of intron 1 were replaced with an inverted neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in embryonic fibroblasts from homozygous mice. (J:178680)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Maml3 Mutation: 36 strains or lines available

References

• Original: J:178680 Oyama T, et al., Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Development. 2011 Dec;138(23):5235-46
• All: 1 reference(s)