Glrx2^tm1Ysh
Targeted Allele Detail

Summary

• Symbol: Glrx2^tm1Ysh
• Name: glutaredoxin 2; targeted mutation Ye-Shih Ho
• MGI ID: MGI:5301815
• Gene: Glrx2 Location: Chr1:143614787-143625416 bp, + strand Genetic Position: Chr1, 62.53 cM, cytoband F
• Alliance: Glrx2^tm1Ysh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178448
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was deleted via homologous recombination. A transcript lacking exon 2 is detected in homozygous mice but western blot analysis did not detect any protein in tissues from homozygous mice. (J:178448)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glrx2 Mutation: 20 strains or lines available

References

• Original: J:178448 Wu H, et al., Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells. Free Radic Biol Med. 2011 Dec 1;51(11):2108-17
• All: 5 reference(s)