Fbxo4^tm1.1Jadi
Targeted Allele Detail

Summary

• Symbol: Fbxo4^tm1.1Jadi
• Name: F-box protein 4; targeted mutation 1.1, J Alan Diehl
• MGI ID: MGI:5301830
• Gene: Fbxo4 Location: Chr15:3994927-4009055 bp, - strand Genetic Position: Chr15, 1.84 cM, cytoband A1
• Alliance: Fbxo4^tm1.1Jadi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178645
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the mammary gland, lung, thymus, spleen, and mouse embryonic fibroblasts. (J:178645)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fbxo4^tm1.1Jadi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo4 Mutation: 25 strains or lines available

References

• Original: J:178645 Vaites LP, et al., The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation. Mol Cell Biol. 2011 Nov;31(22):4513-23
• All: 4 reference(s)