Pag1^tm1Sbln
Targeted Allele Detail

Summary

• Symbol: Pag1^tm1Sbln
• Name: phosphoprotein associated with glycosphingolipid microdomains 1; targeted mutation 1, Sabine Lindquist
• MGI ID: MGI:5301868
• Gene: Pag1 Location: Chr3:9752539-9898739 bp, - strand Genetic Position: Chr3, 2.47 cM
• Alliance: Pag1^tm1Sbln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 6 was replaced with zeo and neo cassettes. Western blot analysis confirmed the absence of protein expression in the brain. (J:177766)

Generation of the Pag1^tm1Sbln allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pag1 Mutation: 21 strains or lines available

References

• Original: J:177766 Lindquist S, et al., Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation. PLoS One. 2011;6(9):e23978
• All: 3 reference(s)