Ddn^tm1Ktry
Targeted Allele Detail

Summary

• Symbol: Ddn^tm1Ktry
• Name: dendrin; targeted mutation 1, Karl Tryggvason
• MGI ID: MGI:5301891
• Gene: Ddn Location: Chr15:98701663-98705806 bp, - strand Genetic Position: Chr15, 54.69 cM
• Alliance: Ddn^tm1Ktry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178223
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with an EGFP-loxP-Ub1-Em7-Neo-loxP. Immunohistochemistry confirmed the absence of protein expression. (J:178223, J:211125)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddn Mutation: 16 strains or lines available

References

• Original: J:178223 Yaddanapudi S, et al., CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 2011 Oct 3;121(10):3965-80
• All: 3 reference(s)