Lmnb2^tm1Yxz
Targeted Allele Detail

Summary

• Symbol: Lmnb2^tm1Yxz
• Name: lamin B2; targeted mutation 1, Yixian Zheng
• MGI ID: MGI:5301971
• Gene: Lmnb2 Location: Chr10:80737197-80754079 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Lmnb2^tm1Yxz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178993
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 1.54-kb proximal promoter region and first exon were replaced by a loxP-flanked neomycin resistance cassette via homologous recombination. (J:178993)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmnb2 Mutation: 27 strains or lines available

References

• Original: J:178993 Kim Y, et al., Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011 Dec 23;334(6063):1706-10
• All: 2 reference(s)