Pomt2^tm1.1Hhu
Targeted Allele Detail

Summary

• Symbol: Pomt2^tm1.1Hhu
• Name: protein-O-mannosyltransferase 2; targeted mutation 1.1, Huaiyu Hu
• MGI ID: MGI:5302103
• Gene: Pomt2 Location: Chr12:87153635-87194742 bp, - strand Genetic Position: Chr12, 41.3 cM
• Alliance: Pomt2^tm1.1Hhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179356
• Parent Cell Line: D2 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:179356)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pomt2 Mutation: 38 strains or lines available

References

• Original: J:179356 Hu H, et al., Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol. 2011 May 1;519(7):1320-37
• All: 2 reference(s)