Crbn^tm1.1Jjh
Targeted Allele Detail

Summary

• Symbol: Crbn^tm1.1Jjh
• Name: cereblon; targeted mutation 1.1, Joseph Higgins
• MGI ID: MGI:5302187
• Gene: Crbn Location: Chr6:106757162-106777038 bp, - strand Genetic Position: Chr6, 49.24 cM, cytoband E2
• Alliance: Crbn^tm1.1Jjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179427
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT site flanked PGK-Neo selection cassette and a loxP site was utilized in the construction of this mutant. This selection cassette was inserted 227 bp upstream of exon 3 of the targeted gene, and another loxP site was inserted 225 bp downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 3 and 4 floxed. (J:179427)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crbn Mutation: 33 strains or lines available

References

• Original: J:179427 Rajadhyaksha AM, et al., Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behav Brain Res. 2012 Jan 15;226(2):428-34
• All: 7 reference(s)