Lzts2^tm1.1Zsu
Targeted Allele Detail

Summary

• Symbol: Lzts2^tm1.1Zsu
• Name: leucine zipper, putative tumor suppressor 2; targeted mutation 1.1, Zijie Sun
• MGI ID: MGI:5302222
• Synonyms: Lzts2^-
• Gene: Lzts2 Location: Chr19:45003615-45015554 bp, + strand Genetic Position: Chr19, 38.2 cM
• Alliance: Lzts2^tm1.1Zsu page

Lzts2^tm1.1Zsu/Lzts2^tm1.1Zsu mice exhibit kidney and urinary tract anomalies

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178154
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP and FRT flanked neo cassette was inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 and 3. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:178154)

Generation of the Lzts2^tm1.1Zsu allele

Disease models

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lzts2 Mutation: 14 strains or lines available

References

• Original: J:178154 Peng Y, et al., The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development. J Biol Chem. 2011 Nov 18;286(46):40331-42
• All: 3 reference(s)